When a deadly symbiote invasion devastates the streets of New York City, only Spider-Man can seize control and bring the city salvation. From the game's direction and outcome through to Spider-Man's destiny, Spider-Man: Web Of Shadows puts control in the player's hands.

Gamers decide when to switch between the agile Red Suit and powerful Black Suit, whether to ally with Marvel's honoured heroes or ferocious villians, which of Spider-Man's abilities to upgrade and what missions to undertake in order to protect Manhattan from certain annihilation.